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Bisphenol A (BPA) is a chemical produced in large quantities for use primarily in the production of polycarbonate plastics. It is found in various products including shatterproof windows, eyewear, water bottles, and epoxy resins that coat some metal food cans, bottle tops, and water supply pipes.

"Recent data show that bisphenols trigger blood-brain barrier dysfunction and memory problems, both hallmarks of Alzheimer's, indicating that environmental bisphenols are a critical yet underrecognized risk factor for the disease.” Alzheimer’s disease (AD) is the most common form of dementia, prevalent in approximately 50–70% of the dementia cases. AD affects memory, and it is a progressive disease interfering with cognitive abilities, behavior and functioning of the person affected. In 2015, there were 47 million people affected by dementia worldwide, and the figure was estimated to increase to 75 million in 2030 and to 132 million by 2050.

In the framework of European Human Biomonitoring Initiative, 18 substances or substance groups were prioritized for investigation. For each of the priority substances, a scoping document was prepared. Based on these scoping documents and complementary review of the recent literature, a scoping review of priority substances which might be associated with AD was conducted. A possible association between risk of AD and pesticides was detected. For mercury (Hg), association is possible but inconsistent. Regarding cadmium (Cd) and arsenic (As), the results are inconsistent but inclined towards possible associations between the substances and the risk of disease. The evidence regarding lead (Pb) was weaker than for the other substances; however, possible associations exist. Although there is evidence of adverse neurological effects of environmental substances, more research is needed. Environmental chemical exposure and the related hazards are essential concerns for public health, and they could be preventable.

Raise a toast to the MIND diet: it recommends a glass of wine every day. Just one, though. Wine rounds out the list of of 10 "brain healthy" food groups that help protect against Alzheimer's: green leafy vegetables, other vegetables, nuts, berries, beans, whole grains, fish, poultry, olive oil and wine. Butter and stick margarine should be limited to less than a tablespoon per day on the MIND diet. Brain-healthy olive, coconut, or Avocado oils can often be used instead.

Curcumin (Turmeric), an ancient Indian herb used in curry powder, has been extensively studied in modern medicine and Indian systems of medicine for the treatment of various medical conditions, including cystic fibrosis, hemorrhoids, gastric ulcer, colon cancer, breast cancer, atherosclerosis, liver diseases and arthritis. It has been used in various types of treatments for dementia and traumatic brain injury. Curcumin also has a potential role in the prevention and treatment of AD. Curcumin as an antioxidant, anti-inflammatory and lipophilic action improves the cognitive functions in patients with AD. A growing body of evidence indicates that oxidative stress, free radicals, beta amyloid, cerebral deregulation caused by bio-metal toxicity and abnormal inflammatory reactions contribute to the key event in Alzheimer's disease pathology.

MSM a natural sulphur found in fresh water sources that are uncontaminated by man has been studied and can be purchased at health food stores to add to your daily water intake. The results showed that MSM reduced ethanol-mediated oxidative stress by decreasing the levels of malondialdehyde (MDA) and carbonyl protein. The Nrf2/HO-1 pathway and the levels of cytoprotective antioxidants superoxide dismutase (SOD), catalase and glutathione (GSH) were increased by MSM in the brain tissue.Since it's effective in reducing levels of inflammatory compounds like IL-6 and TNF-a, MSM may reduce stress on your immune system. Additionally, it plays a part in the creation of glutathione, your body's master antioxidant. It may also help increase levels of this important compound.

Glutathione is a substance made from the amino acids glycine, cysteine, and glutamic acid. It is produced by the liver and involved in many body processes.Your cells contain glutathione, which is a substance made from three amino acids: cysteine, glutamate, and glycine. Glutathione acts as an important antioxidant in your body. That means it helps combat free radicals. These are molecules that can damage your body's cells.Glutathione, a powerful antioxidant, crucial for detox and immunity. Foods like garlic, onions, cruciferous veggies, avocado, spinach, walnuts, tomatoes, and asparagus support its production and cellular health. Scientific evidence confirms that a low content of glutathione can impair short-term and long-term mechanisms of synaptic plasticity . Furthermore, the maintenance of normal glutathione levels are important for acquisition memory ,meaning learning new things.

The underlying biochemistry implicates low GSH as an important contributing factor in the development of several chronic illnesses that have been associated with increased oxidative stress such as metabolic syndrome, kidney disease, neurodegenerative diseases, liver disease, and cardiovascular diseases. Among the 12 lifestyle factors, obesity caused by high processed sugar intake, high blood pressure and inflammation, and lack of exercise contributed the most to risk of dementia. Reducing these modifiable risk factors would reduce dementia prevalence.


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